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Caring for people with COVID-19

Supporting Australia’s healthcare professionals with continually updated, evidence-based clinical guidelines

24/09/20: Weekly Communique from the National Steering Committee

Latest Guidance

24 September 2020

Updates this week include:

Living
guidelines

High-priority, evidence-based clinical COVID-19 guidelines updated weekly with the latest research

We have developed recommendations that cover:

  • Definition of disease severity
    • Definition of disease severity for adults
    • Definition for disease severity for children and adolescents
  • Monitoring and markers of clinical deterioration
  • Disease-modifying treatments new
    • Corticosteroids
      • Corticosteroids for adults
      • Corticosteroids for pregnant or breastfeeding women
      • Corticosteroids for children or adolescents
    • Remdesivir
      • Remdesivir for adults
      • Remdesivir for pregnant patients
      • Remdesivir for children or adolescents
    • Hydroxychloroquine
    • Disease-modifying treatments not recommended outside of clinical trials new
      • Aprepitant
      • Azithromycin new
      • Baloxavir marboxil
      • Calcifediol
      • Chloroquine
      • Colchicine
      • Convalescent plasma
      • Darunavir-cobicistat
      • Favipiravir
      • Human umbilical cord mesenchymal stem cells
      • Immunoglobulin plus methylprednisolone
      • Interferon β-1a
      • Interferon β-1b
      • Interferon gamma
      • Lopinavir/ritonavir
      • Ruxolitinib
      • Sofosbuvir-daclatasvir
      • Telmisartan
      • Umifenovir
    • Other disease modifying treatments
  • Chemoprophylaxis
    • Hydroxychloroquine for post-exposure prophylaxis
  • Respiratory support in adults
    • High-flow nasal oxygen therapy
    • Non-invasive ventilation
    • Respiratory management of the deteriorating patient
    • Videolaryngoscopy
    • Neuromuscular blockers
    • Positive end-expiratory pressure (PEEP)
    • Prone positioning
      • Prone positioning for adults
      • Prone positioning for pregnant and postpartum women
    • Recruitment manoeuvres
    • Extracorporeal membrane oxygenation (ECMO)
      • ECMO for adults
      • ECMO for pregnant and postpartum women
  • Respiratory support in neonates, children and adolescents
    • Requiring non-invasive respiratory support
      • High-flow nasal oxygen and non-invasive ventilation
      • Prone positioning (non-invasive)
      • Respiratory management of the deteriorating child
    • Requiring invasive mechanical ventilation
      • Prone positioning (mechanical ventilation)
      • Positive end-expiratory pressure (PEEP)
      • Recruitment manoeuvres
      • Neuromuscular blockers
      • High-frequency oscillatory ventilation (HFOV)
      • Videolaryngoscopy
      • Extracorporeal membrane oxygenation (ECMO)
  • Venous thromboembolism (VTE) prophylaxis
    • VTE prophylaxis for adults
    • VTE prophylaxis for pregnant and postpartum women
  • Therapies for pre-existing conditions in patients with COVID-19
    • ACEIs/ARBs in patients with COVID-19
    • ACEIs in postpartum women
    • Steroids for people with asthma or COPD with COVID-19
  • Pregnancy and perinatal care
    • Antenatal corticosteroids
    • Mode of birth
    • Delayed umbilical cord clamping
    • Skin-to-skin contact
    • Breastfeeding
    • Rooming-in
  • Child and adolescent care

View all evidence-based recommendations here:

We will revise and add recommendations each week as our evidence teams and expert panels identify priority clinical questions and synthesise new research.

Clinical
flowcharts

Flowcharts incorporating living guideline recommendations and guidance issued or endorsed by Taskforce members

We have developed clinical flowcharts that cover:

Updates to flowcharts this week reflect:

  • Azithromycin added to the 'only in research' category
  • Advice on the use of pulse oximeters updated in mild chart
  • 'Setting of care' and 'discharge planning' sections updated in moderate to severe chart.
  • New section 'discharge planning' added to severe to critical chart

Evidence
under review

Continuously reviewing new evidence to update recommendations and address new priority questions

We are currently reviewing evidence to develop recommendations and flowcharts to guide practice in areas including:

  • Combination hydroxychloroquine plus azithromycin new
  • Tocilizumab
  • Umifenovir
  • Recombinant human granulocyte colony-stimulating factor
  • Cardiac arrest
  • Paediatric Multisystem Inflammatory Syndrome (PIMS-TS)

Do you have a clinical question?

Your views help us to identify and prioritise questions to include in the living guideline.

Check if your question is already being considered

Submit your questions here

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PERSONAL DETAILS

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SUGGESTIONS

Suggest a new topic or clinical question. Please note that our living guideline aims to

“Provide specific, patient-focused recommendations for the clinical care of people with suspected or confirmed COVID-19, where care for this patient group differs from usual care provided to patients with similar clinical conditions (pneumonia, severe acute respiratory distress, etc.)”.

*The following topics are currently included:
• Definition of disease severity
• Monitoring and markers of clinical deterioration
• Disease modifying treatments (e.g. antimalarials)
• Respiratory support
• Corticosteroids
• Anticoagulants
• ACE-I/ARBs

AGREEMENTS

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COVID-19
Research

Find COVID-19 studies around the world

 

Cochrane’s COVID-19 Study Register is a freely-available, continually-updated, annotated reference collection of human studies on COVID-19, including interventional, observational, diagnostic, prognostic, epidemiological, and economic designs.

Find COVID-19 studies in Australia

 

The ANZCTR is an online registry of clinical trials being undertaken in Australia, New Zealand and elsewhere. A list of coronavirus/COVID-19 studies currently recruiting in Australia is available here.

Core Outcomes for COVID-19 Research

 

The COVID-19-COS project is an international initiative bringing together patients, the public and health professionals to identify, prioritise and agree on the most important outcomes for research in COVID-19.

Partners
and funders