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High-priority, evidence-based clinical COVID-19 guidelines updated with the latest research

Clinical care guidelines

We have developed recommendations that cover:

  • Definition of disease severity
    • Definition of disease severity for adults
    • Definition for disease severity for children and adolescents
  • Monitoring and markers of clinical deterioration
  • Disease-modifying treatments new
    • Recommended disease-modifying treatments new
      • Budesonide for adults
      • Budesonide for children and adolescents new
      • Casirivimab plus imdevimab (Ronapreve/REGEN-COV) for adults
      • Casirivimab plus imdevimab (Ronapreve/REGEN-COV) for pregnant or breastfeeding women
      • Casirivimab plus imdevimab (Ronapreve/REGEN-COV) for children and adolescents new
      • Systemic corticosteroids
        • Corticosteroids for adults
        • Corticosteroids for pregnant or breastfeeding women updated
        • Corticosteroids for children or adolescents
      • Other immunomodulating drugs
        • Baracitinib
        • Sarilumab
        • Tocilizumab
      • Sotrovimab new
        • Sotrovimab for adults
        • Sotrovimab for pregnant women
        • Sotrovimab for children and adolescents new
      • Remdesivir
        • Remdesivir for adults
        • Remdesivir for pregnant or breastfeeding women
        • Remdesivir for children or adolescents
    • Disease-modifying treatments that are not recommended
      • Aspirin
      • Azithromycin
      • Colchicine
      • Convalescent plasma
      • Hydroxychloroquine
      • Hydroxychloroquine plus azithromycin
      • Interferon β-1a
      • Interferon β-1a plus lopinavir-ritonavir
      • Lopinavir-ritonavir
    • Disease-modifying treatments not recommended outside of clinical trials
      • Antiandrogens
        • Dutasteride
      • Antineoplastics
        • Angiotensin 2 receptor agonist (C21)
        • Camostat mesilate
      • Antiparasitic, antifungals and other anti-infective agents
        • Chloroquine
        • Doxycycline new
        • Ivermectin
        • Ivermectin plus doxycycline
        • Nitazoxanide
      • Antihypertensives
        • Telmisartan
      • Antithrombotic, antiplatelets and related therapies
        • Sulodexide
      • Antivirals
        • Baloxavir marboxil
        • Darunavir-cobicistat
        • Enisamium
        • Favipiravir
        • Sofosburiv-daclatasvir
        • Triazavirin
        • Umifenovir
      • Human and blood derived products
        • Human umbilical cord mesenchymal stem cells
        • Intravenous immunoglobulin
        • Intravenous immunoglobulin plus methylprednisolone
      • Immunomodulating drugs
        • Anakinra
        • Lenzilumab
        • Ruxolitinib
        • Tofacitinib
      • Interferons
        • Interferon β-1a (inhaled)
        • Interferon β-1b
        • Interferon gamma
        • Interferon kappa plus trefoil factor 2 (IFN-κ plus TFF2)
        • Peginterferon lambda
      • Other antibody related therapies
        • Bamlanivimab
        • Bamlanivimab plus etesevimab
        • CT-P59 monoclonal antibody
      • Other therapies
        • Aprepitant
        • Bromhexine hydrochloride
        • Fluvoxamine Updated evidence/No change
        • Recombinant human granulocyte colony-stimulating factor (rhG-CSF)
      • Vitamins, supplements and cofactors
        • Combined metabolic cofactor supplementation (CMCS)
        • N-acetylcysteine
        • Vitamin C
        • Vitamin D analogues (calcifediol/cholecalciferol)
        • Zinc
      • Other disease-modifying treatments
    • Disease-modifying treatments under review
      • Canakinumab
      • Imatinib
      • Metformin
      • Proxalutamide
  • Chemoprophylaxis
    • Casirivimab plus imdevimab (Ronapreve/REGEN-COV) for post-exposure prophylaxis
    • Hydroxychloroquine for pre-exposure prophylaxis
    • Hydroxychloroquine for post-exposure prophylaxis
  • Respiratory support in adults
    • Continuous positive airway pressure / High-flow nasal oxygen therapy new
    • Non-invasive ventilation
    • Respiratory management of the deteriorating patient
    • Videolaryngoscopy
    • Neuromuscular blockers
    • Positive end-expiratory pressure (PEEP)
    • Prone positioning
      • Prone positioning for adults updated
      • Prone positioning for pregnant and postpartum women
    • Recruitment manoeuvres
    • Extracorporeal membrane oxygenation (ECMO)
      • ECMO for adults
      • ECMO for pregnant and postpartum women
  • Respiratory support in neonates, children and adolescents
    • Requiring non-invasive respiratory support
      • High-flow nasal oxygen and non-invasive ventilation
      • Prone positioning (non-invasive)
      • Respiratory management of the deteriorating child
    • Requiring invasive mechanical ventilation
      • Prone positioning (mechanical ventilation)
      • Positive end-expiratory pressure (PEEP)
      • Recruitment manoeuvres
      • Neuromuscular blockers
      • High-frequency oscillatory ventilation (HFOV)
      • Videolaryngoscopy
      • Extracorporeal membrane oxygenation (ECMO)
  • Venous thromboembolism (VTE) prophylaxis
    • VTE prophylaxis for adults
    • VTE prophylaxis for pregnant and postpartum women
    • VTE prophylaxis for children and adolescents
  • Therapies for existing indications in patients with COVID-19
    • ACEIs/ARBs in patients with COVID-19
    • ACEIs in postpartum women
    • Steroids for people with asthma or COPD with COVID-19
    • Oestrogen-containing therapies
  • Timing of surgery following COVID-19 infection
  • Pregnancy and perinatal care
    • Antenatal corticosteroids
    • Magnesium sulfate
    • Mode of birth
    • Delayed umbilical cord clamping
    • Skin-to-skin contact
    • Breastfeeding
    • Rooming-in
  • Child and adolescent care
    • Paediatric Inflammatory Multisystem Syndrome (PIMS-TS)
      • Intravenous immunoglobulin (IVIG) plus corticosteroids
      • Corticosteroids
      • Other immunomodulatory agents
      • Aspirin and antithrombotic agents

View all evidence-based recommendations here:

We will revise and add recommendations each week as our evidence teams and expert panels identify priority clinical questions and synthesise new research.


Flowcharts incorporating living guideline recommendations and guidance issued or endorsed by Taskforce members

under review

Continuously reviewing new evidence to update recommendations and address new priority questions

We are currently reviewing evidence to develop recommendations and flowcharts to guide practice in areas including:

  • Canakinumab
  • Corticosteroids
  • Doxycycline
  • Fluvoxamine
  • Hydroxychloroquine plus azithromycin
  • Imatinib
  • Immunoglobulin plus methylprednisolone
  • Proxalutimide
  • Tocilizumab
  • Care of people with Post-acute COVID-19

Preventing infection in healthcare workers

We have developed recommendations that cover:

View recommendations here:

Do you have a clinical question?

Your views help us to identify and prioritise questions to include in the living guideline.

Check if your question is already being considered

Submit your questions here

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Suggest a new topic or clinical question. Please note that our living guideline aims to

“Provide specific, patient-focused recommendations for the clinical care of people with suspected or confirmed COVID-19, where care for this patient group differs from usual care provided to patients with similar clinical conditions (pneumonia, severe acute respiratory distress, etc.)”.

*The following topics are currently included:
• Definition of disease severity
• Monitoring and markers of clinical deterioration
• Disease modifying treatments (e.g. antimalarials)
• Respiratory support
• Corticosteroids
• Anticoagulants


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Find COVID-19 studies around the world

Cochrane’s COVID-19 Study Register is a freely-available, continually-updated, annotated reference collection of human studies on COVID-19, including interventional, observational, diagnostic, prognostic, epidemiological, and economic designs.

Find COVID-19 studies in Australia

The ANZCTR is an online registry of clinical trials being undertaken in Australia, New Zealand and elsewhere. A list of coronavirus/COVID-19 studies currently recruiting in Australia is available here.

Core Outcomes for COVID-19 Research

The COVID-19-COS project is an international initiative bringing together patients, the public and health professionals to identify, prioritise and agree on the most important outcomes for research in COVID-19.

and funders